Everything about Asparaginase totally explained
Asparaginase is an
enzyme that catalyzes the
hydrolysis of
asparagine to
aspartic acid. It is marketed under the brand name
'Elspar, to treat
acute lymphoblastic leukemia (ALL) and is also used in some
mast cell tumor protocols. Unlike other chemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation.
Mechanism of action
The rationale behind asparaginase is that it takes advantage of the fact that ALL leukemic
cells are unable to synthesize the
non-essential amino acid asparagine whereas normal cells are able to make their own asparagine.leukemic cells require high amount of asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to
aspartic acid and
ammonia. This deprives the leukemic cell of circulating asparagine.
Side effects
The main
side effect is an
allergic or hypersensitivity reaction. Asparaginase has also been associated with
pancreatitis. Additionally, it can also be associated with a
coagulopathy as it decreases protein synthesis, including synthesis of coagulation factors and anticoagulant factor, leading to
bleeding or
thrombotic events such as stroke.
Further Information
Get more info on 'Asparaginase'.
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